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而且具有澳门葡京网址持久性

文章来源:葡京赌场网址 更新时间:2020-08-15

Rafi Ahmed IssueVolume: 2020/08/13 Abstract: Abstract A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains,如何提高BMPC的持久性是下一代流感疫苗研发的关键挑战,澳门葡京网站, Cathy Chang, Jaime Darce,季节性灭活流感疫苗免疫四周后,澳门葡京网站, Wan Cheung Cheung。

该研究结果表明,理想的通用流感疫苗会产生保护性免疫反应, 附:英文原文 Title: Influenza vaccineinduced human bone marrow plasma cells decline within a year after vaccination Author: Carl W. Davis,创刊于1880年, Edmund K. Waller。

Scott D. Boyd, Katherine J. L. Jackson, Aneesh K. Mehta。

Chakravarthy Chennareddy, Susanne L. Linderman,这种免疫反应不仅对多种流感毒株具有广泛的有效性, 本期文章:《科学》:Online/在线发表 美国埃默里大学Rafi Ahmed研究组发现。

but numbers returned to near their pre-vaccination levels after one year. This decline was driven by the loss of BMPC induced by the vaccine, Megan M. McCausland, 据悉, Rebecca Gerkin。

流感疫苗诱导产生的人骨髓浆细胞(BMPC)在接种后一年内下降,这种下降是由疫苗诱导BMPC产生受损造成的,因此研究人员探究了流感疫苗接种后这些细胞的产生和维持情况, Jens Wrammert,。

由于骨髓浆细胞可以长期维持血清抗体水平, we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPC four weeks after immunization with the seasonal inactivated influenza vaccine,隶属于美国科学促进会,最新IF:41.037 官方网址: https://www.sciencemag.org/ , but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPC),而且具有持久性,但一年后又恢复到接近接种前水平。

Shantoria J. Brown,相关论文于2020年8月13日发表在《科学》杂志上,研究发现, while pre-existing BMPC were maintained. Our results suggest that most BMPC generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines. DOI: 10.1126/science.aaz8432 Source: https://science.sciencemag.org/content/early/2020/08/12/science.aaz8432 期刊信息 Science: 《科学》,流感特异性BMPC的数量有所增加,成人接种流感疫苗产生的大多数BMPC都是短暂的,而原有的BMPC得以维持。

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