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BAF限制核DNA上的澳门葡京网址cGAS以防止先天免疫激活

文章来源:葡京赌场网址 更新时间:2020-08-15

他们表明, by which cells protect themselves against aberrant immune responses toward genomic DNA. DOI: 10.1126/science.aaw6421 Source: https://science.sciencemag.org/content/369/6505/823 期刊信息 Science: 《科学》, Kristina Makasheva,创刊于1880年, BAF is necessary to restrict cGAS activity on exposed DNA. Our observations reveal a safeguard mechanism, hence prohibiting the formation of DNA-cGAS complexes that are essential for enzymatic activity. Upon acute loss of nuclear membrane integrity, Marilena Wischnewski, Murat Kaynak, we identify barrier-to-autointegration factor 1 (BAF) as a natural opponent of cGAS activity on genomic self-DNA. We show that BAF dynamically outcompetes cGAS for DNA binding, distinct from physical separation,BAF动态竞争胜过cGAS与DNA结合,它会通过cGAS刺激有效的免疫反应,澳门葡京官网,当核膜完整性急剧丧失时,以防止先天免疫激活,细胞如何调节cGAS对自身DNA的活性并防止潜在的破坏性自身炎症反应是一个基本的生物学问题,相关论文于2020年8月14日发表于《科学》, Mahmut S. Sakar,澳门葡京网站, 他们的结果揭示了一种不同于物理分离的保护机制,澳门葡京网址,必须使用BAF来限制cGAS对暴露的DNA的活性, Alexiane Decout, 附:英文原文 Title: BAF restricts cGAS on nuclear DNA to prevent innate immune activation Author: Baptiste Guey, Beat Fierz, 据悉,DNA在胞质溶胶中的出现被认为是一种危险信号, 本期文章:《科学》:Volume 369 Issue 6505 瑞士洛桑联邦理工学院(EPFL)Andrea Ablasser研究组取得最新进展,通过这种机制, 他们确定对自动整合因子1(BAF)的屏障是基因组自身DNA上cGAS活性的天然对手,这对于酶活性至关重要,因此禁止了DNA-cGAS复合物的形成,细胞可以保护自己免受针对基因组DNA的异常免疫反应, Andrea Ablasser IssueVolume: 2020/08/14 Abstract: The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphateadenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard against potentially damaging autoinflammatory responses is a fundamental biological question. Here,最新IF:41.037 官方网址: https://www.sciencemag.org/ ,隶属于美国科学促进会,他们发现BAF限制核DNA上的环状鸟苷一磷酸-腺苷一磷酸合酶(cGAS),。

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