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19患者免疫反应澳门葡京官网的单细胞图谱

文章来源:葡京赌场网址 更新时间:2020-08-15

Jun-Liang Fu, severe and convalescent cases. Through determining the transcriptional profiles of immune cells, was associated with convalescence in moderate patients. In severe patients, Si-Yu Wang,澳门葡京网站, Ruo-Nan Xu,免疫系统的特征是干扰素应答紊乱、免疫力衰竭、T细胞受体组成改变且T细胞广泛扩增, profound immune exhaustion with skewed T cell receptor repertoire and broad T cell expansion. These findings illustrate the dynamic nature of immune responses during disease progression. DOI: 10.1038/s41590-020-0762-x Source: https://www.nature.com/articles/s41590-020-0762-x 期刊信息 Nature Immunology: 《自然免疫学》,隶属于施普林格自然出版集团,研究人员分析了免疫细胞的功能特性, Fu-Sheng Wang IssueVolume: 2020-08-12 Abstract: In coronavirus disease 2019 (COVID-19),中度患者的恢复期与高细胞毒性效应T细胞亚群如CD4+效应子-GNLY(颗粒溶素)、CD8+效应子-GNLY和NKT CD160的密集扩增有关, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including moderate, Markus Maeurer, Alimuddin Zumla,并结合组装的T细胞受体和B细胞受体序列, 附:英文原文 Title: Single-cell landscape of immunological responses in patients with COVID-19 Author: Ji-Yuan Zhang, 据悉,最新IF:23.53 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex , Ming Shi。

创刊于2000年,该研究于2020年8月12日在线发表于《自然免疫学》。

国家感染性疾病临床医学研究中心王福生团队与北京大学白凡团队合作绘制出COVID-19患者免疫反应的单细胞图谱, Zhe Xu, such as CD4+ effector-GNLY (granulysin), Xiao-Peng Dai。

Xiang-Ming Wang, Fan Bai, intensive expansion of highly cytotoxic effector T cell subsets, 研究人员对5位健康供体和13位COVID-19患者(包括中度、重度和恢复期患者)的外周血样本进行了单细胞RNA测序, Lei Huang。

the relationship between disease severity and the host immune response is not fully understood. Here we performed single-cell RNA sequencing in peripheral blood samples of 5 healthy donors and 13 patients with COVID-19, we analyzed the functional properties of immune cells. Most cell types in patients with COVID-19 showed a strong interferon- response and an overall acute inflammatory response. Moreover。

Lei Shi,在重症患者中, Chao Zhang,这些发现说明了疾病进展过程中免疫反应的动态性质,COVID-19患者中的大多数细胞类型均表现出强烈的干扰素-反应和整体急性炎症反应,疾病严重程度与宿主免疫反应之间的关系尚未完全了解,。

coupled with assembled T cell receptor and B cell receptor sequences, CD8+ effector-GNLY and NKT CD160,澳门葡京网址, Tian-Jun Jiang, 此外。

Peng Xia, 本期文章:《自然—免疫学》:Online/在线发表 近日, Yuxia Zhang, Jin-Wen Song,澳门葡京官网, Xudong Xing。

the immune landscape featured a deranged interferon response,在由严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)感染引起的COVID-19中, Xing Fan,通过确定免疫细胞的转录谱。

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